ANDREW J. PIERCE, Ph.D.
curriculum vitae

Contact Information

Office Address
University of Kentucky
Markey Cancer Center
207 Combs Research Building
800 Rose Street
Lexington, KY 40536-0096
Telephone: (859) 323-1455
FAX: (859) 257-8940
E-mail: andrew.pierce@uky.edu

Lab Address
University of Kentucky
Markey Cancer Center
222 Combs Research Building
800 Rose Street
Lexington, KY 40536-0096
Telephone: (859) 323-1649
Web: http://www.paralog.com/ajp/

Current Position

2003 - present

Assistant Professor, College of Medicine
Markey Cancer Center and
Department of Microbiology, Immunology and Molecular Genetics
University of Kentucky

Post-Doctoral Research

1997 - 2003

Maria Jasin

DNA double-strand break stimulated homologous recombination in mammalian cells. Memorial Sloan-Kettering Cancer Center, New York, NY.

1995 - 1997

Paul Modrich

Biochemical mechanisms of mammalian DNA mismatch repair. Department of Biochemistry, Duke University, Durham, NC.

Education

1990 - 1995

Doctor of Philosophy
Genetics

"Exploration of an Evolutionarily Conserved DNA Sequence Element in the Hamster Dihydrofolate Reductase Promoter."
Performed under the direction of Dr. Jane Clifford (Azizkhan).
Curriculum in Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.

1986 - 1990

Bachelor of Science
(Honors)

Specialist in Molecular Genetics and Molecular Biology, Major in Astronomy, Minor in Philosophy.
University of Toronto, Toronto, Ontario, Canada.


Publications
(PDF help)
2010 Thiyam Ramsing Singh, Dorina Saro, Abdullah Mahmood Ali, Xiao-feng Zheng, Chang-hu Du, Michael W. Killen, Aristidis Sachpatzidis, Kebola Wahengbam, Andrew J. Pierce, Yong Xiong, Patrick Sung and Amom Ruhikanta Meetei.
MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.
Molecular Cell 37: 879-86.
PubMed
PDF
2009 Dawn M. Stults, Michael W. Killen, Erica P. Williamson, Jon S. Hourigan, H. David Vargas, Susanne M. Arnold, Jeffrey A. Moscow and Andrew J. Pierce.
Human ribosomal RNA gene clusters are recombinational hotspots in cancer.
Cancer Research 69: 9096-104.
PubMed
PDF
2009 Michael W. Killen, Dawn M. Stults, Noritaka Adachi, Les Hanakahi and Andrew J. Pierce.
Loss of Bloom syndrome protein destabilizes human gene cluster architecture.
Human Molecular Genetics 18(18): 3417-3428.
PubMed
PDF
2009 Jasmina Kurepa, Songhu Wang, Yan Li, David Zaitlin, Andrew J. Pierce and Jan A. Smalle.
Loss of 26S proteasome function leads to increased cell size and decreased cell number in Arabidopsis shoot organs.
Plant Physiology
150(1): 178-189.
PubMed
PDF
2008 Dawn M. Stults, Michael W. Killen, Heather H. Pierce, Andrew J. Pierce.
Genomic architecture and inheritance of human ribosomal RNA gene clusters.
Genome Research 18(1): 13-18.
PubMed
PDF
2005 Ranjit S. Bindra, Shannon L. Gibson, Alice Meng, Ulrica Westermark, Maria Jasin, Andrew J. Pierce, Robert G. Bristow, Marie K. Classon and Peter M. Glazer.
Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.
Cancer Research
65(24): 11597-11604.
PubMed
PDF
2005
Koji Nakanishi, Yun-Gui Yang, Andrew J. Pierce, Toshiyasu Taniguchi, Martin Digweed, Alan D. D’Andrea, Zhao-Qi Wang and Maria Jasin.
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.
Proceedings of the National Academy of Science
102(4): 1110-1115.
PubMed
PDF

2004

Andrew J. Pierce and Maria Jasin.
Measuring recombination proficiency in mouse embryonic stem cells.
Methods in Molecular Biology 291:373-384.

PubMed
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2004

Jeremy M. Stark, Andrew J. Pierce, Jin Oh, Albert Pastink and Maria Jasin.
Genetic steps of mammalian homologous repair with distinct mutagenic consequences.
Molecular and Cellular Biology 24(21): 9305-9316.

PubMed
PDF

2002

Felipe D. Araujo, Andrew J. Pierce, Jeremy M. Stark and Maria Jasin.
Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks.
Oncogene 21(26): 4176-4180.

PubMed
PDF

2002

Jeremy M. Stark, Peng Hu, Andrew J. Pierce, Mary Ellen Moynahan, Nathan Ellis, and Maria Jasin.
ATP-hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair.
Journal of Biological Chemistry 277(23): 20185-20194.

PubMed
PDF

2002

Claudia Wiese, Andrew J. Pierce, Stacey S. Gauny, Maria Jasin and Amy Kronenberg.
Gene conversion is strongly induced in human cells by double-strand breaks and is modulated by the expression of BCL-xL.
Cancer Research 62(5): 1279-1283.

PubMed
PDF

2001

Andrew J. Pierce and Maria Jasin.
NHEJ deficiency and disease.
Molecular Cell 8(6): 1160-1161.

PubMed
PDF

2001

Andrew J. Pierce, Peng Hu, Mingguang Han, Nathan Ellis and Maria Jasin.
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells.
Genes and Development 15(24): 3237-3242.

PubMed
PDF

2001

Artur Slupianek, Christoph Schmutte, Gregory Tombline, Malgorzata Nieborowska-Skorska, Grazyna Hoser, Michal O. Nowicki, Andrew J. Pierce, Richard Fishel and Tomasz Skorski.
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.
Molecular Cell 8(4): 795-806.

PubMed
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2001

Andrew J. Pierce, Jeremy M. Stark, Felipe D. Araujo, Mary Ellen Moynahan, Marianne Berwick and Maria Jasin.
Double-strand breaks and tumorigenesis.
Trends in Cell Biology 11(11): S52-59.

PubMed
PDF

2001

Mary Ellen Moynahan, Andrew J. Pierce and Maria Jasin.
BRCA2 is required for homology-directed repair of chromosomal breaks.
Molecular Cell 7(2): 263-272.

PubMed
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1999

Andrew J. Pierce, Roger D. Johnson and Maria Jasin.
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.
Genes and Development 13(20): 2633-2638.

PubMed
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1997

Matthew J. Longley, Andrew J. Pierce and Paul Modrich.
DNA Polymerase δ is Required for Human Mismatch Repair in Vitro.
Journal of Biological Chemistry 272(16): 10917-10921.

PubMed
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1993

Jane C. Azizkhan, David E. Jensen, Andrew J. Pierce, and Michael Wade.
Transcription from TATA-less Promoters: Dihydrofolate Reductase as a Model.
Critical Reviews in Eukaryotic Gene Expression 3(4): 229-254.

PubMed

1992

Andrew J. Pierce, Robert C. Jambou, David E. Jensen and Jane Clifford Azizkhan.
A Conserved DNA Structural Control Element Modulates Transcription of a Mammalian Gene.
Nucleic Acids Research 20(24): 6583-6587.

PubMed
PDF

Professional Service
2010 - 2012 Associate Editor, American Journal of Translational Research
2009 - 2012 Associate Editor, BMC Molecular Biology
Grants and Awards
2008 Kentucky Lung Cancer Research Program
"The gene cluster instability assay as clinical lung cancer biomarker."
2007 NCI Developmental Therapeutics Program
"Screening for genomic instability of the ribosomal RNA gene clusters in the NCI-60 cell line panel."
2007 American Cancer Society
"Analysis of genomic recombination in human cancer patients."
2005 UK Executive Vice President for Research
"Drug-mediated rearrangements in human cells."

2003

American Cancer Society
"Chromosomal rearrangement in response to DNA double-strand breaks."

2000

Fanconi Anemia Research Fund
"Genetic Instability of FA cells: a possible role for homologous recombination."

1992 - 1994

National Science Foundation Pre-doctoral Fellowship

1990

University of North Carolina at Chapel Hill Merit Assistantship

1987

Trinity College Merit Scholarship

1986

University of Toronto J.W. Billes Entrance Scholarship