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DnaRepairGene
DnaRepairGene
see also: http://www.cgal.icnet.uk/DNA_Repair_Genes.html

cerevisiae
pombe
E. coli
human
function
Rad51, Dmc1(meiotic)
rhp51
RecA
Rad51, Rad51-B,C,D, XRCC-2,3 Dmc1(meiotic)
strand invasion, (h)lethal
Rad52
rad22A, rad22B(meiotic) rti1(similar)

rad52
strand annealing, assist rad51, very subtle human function
Rad54
rhp54

rad54-A,B/ATR-X/HX2
chromatin remodeling
Rdh54/tid1
rdh54

rad54-B
second rad54 homolog
Rad55
rhp55

xrcc2-3?
assist rad51
Rad57
rhp57

xrcc2-3?
assist rad51



XRCC1
nick repair (with pol β and DNA ligase III)
Rad55/57?
rhp55/57?

XRCC2
part of Rad51-B,C,D,X2 complex
Rad55/57?
rhp55/57?

XRCC3
part of Rad51-C,X3 complex. resolve Holliday junctions?
Rad50
rad50

rad50
trim DSB ends. rad50/mre11/xrs2 (MRX) complex
Mre11
rad32

mre11
trim DSB ends. rad50/mre11/xrs2 (MRX) complex
Xrs2
nbs1

nbs1
trim DSB ends. rad50/mre11/xrs2 (MRX) complex
Sae2
Ctp1

CtIP (Ctp1)
nuclease to allow initial DSB 5' resection (with MRX complex)
Dna2


Dna2
main nuclease to allow DSB 5' resection
exoI


exoI
alternative / contributory nuclease to allow DSB 5' resection
srs2


rtel1
remove rad51 from ssDNA
yku70/hdf1


Ku70/XRCC6
endjoining, heterdimer with Ku80
yku80/hdf2


Ku80/XRCC5
endjoining, heterodimer with Ku70
not found


DNA-PKcs/XRCC7
DNA-dependent kinase, partners with Ku70/80 heterdimer
lif1


XRCC4
heterodimer with lig4
dnl4


lig4
ligase, heterodimer with xrcc4



XRCC9/Fanc-G
Fanconi anemia complementation group G



XRCC11/BRCA2/Fanc-D1
hereditary breast cancer, Fanconi anemia

rad9

rad9
rad9/hus1/rad1 hetertrimer, repair polymerase sliding clamp loader (RFC equivalent)?

rad1

rad1
part of "911" complex with rad9 and hus1

hus1

hus1
part of "911" complex with rad9 and rad1, hydroxyurea sensitive



XPA
NER; xeroderma pigmentosum
rad25/ssl2


XPB/ERCC3
NER; xeroderma pigmentosum, cockayne's, tricothiodystrophy
rad4


XPC
global genome NER (only); xeroderma pigmentosum
rad23


HR23A / HR23B
XPC cofactors



cen2
XPC cofactor
rad3

XPD/ERCC2
NER, G2 checkpoint; xeroderma pigmentosum, cockayne's, tricothiodystrophy



XPE
NER; xeroderma pigmentosum
rad1
rad16/swi9

XPF/ERCC4
heterodimer with (sc)rad10, cut off 3' ended ss flaps; xeroderma pigmentosum
rad10
swi10

ERCC1
heterodimer with (sc)rad1, 5' (wrt damage) NER flap endonuclase
rad27/fen1
rad2/fen1
N-term of DNA polI (polN)
XPG/ERCC5
NER; cut 5' ended ss flaps
rad2


XPG
NER, early-onset cockayne's (transcription coupled repair)



CSA/ERCC8
transcription coupled repair (Cockayne's)
rad26


CSB/ERCC6
cockayne's syndrome (transcription coupled repair)
rad13


NER
rad15


NER
rad17


G2 checkpoint
ddc2?
rad26


G2 checkpoint
msh2

mutS
msh2
msh2/3 or msh2/6 heterdimer, mismatch repair of bases, loops
msh3

mutS
msh3
msh2/3 heterdimer, mismatch repair of loops
msh6/gtbp

mutS
msh6
msh2/6 heterodimer, mismatch repair of bases
mlh1

mutL
mlh1
mlh1/(h)pms2 heterodimer, mismatch repair
pms1

mutL
pms2
mlh1/(h)pms2 heterodimer, mismatch repair
pms2

mutL
pms1
sgs1



helicase to allow DSB 5' resection
sgs1
rqh1
recQ
recql1
assists BLM? no disease known
sgs1
rqh1
recQ
WRN/recql2
Werner syndrome
sgs1
rqh1
recQ
BLM/recql3
Bloom syndrome
sgs1
rqh1
recQ
RTS/recql4
Rothmund-Thompson syndrome
sgs1
rqh1
recQ
recql5
assists BLM? no disease known
yen1


GEN1
Holliday junction resolution
mec1
rad3

ATR
replication fork failure checkpoint, (h)lethal
tel1


ATM
DSB checkpoint, ataxia-telangiectasia
rad53


chk2
checkpoint signal transducer

uvrA, uvrB

holliday junction branch migration

uvrC

holliday junction resolvase

rusA

holliday junction resolvase
mus81
mus81

mus81
similar to Rad1/10 but more active on branches than flaps
mms4
eme1

hMMS4
accessory to mus81, branch nickase
spo11
rec12

spo11
generate meiotic double-strand breaks for synapsis/recombination
rfa1
rad11


largest subunit of the heterotrimeric eukaryotic single-stranded binding protein RPA
Rev3


DNA pol ζ
Pol Zeta, catalytic subunit, translesion polymerase
Rev7


DNA pol ζ
Pol Zeta, accessory component, translesion polymerase
Rad30


DNA pol η
Pol Eta, translesion polymerase, deficient in XP-V, one of the DNA polymerases to extend HR D-loops

Michael You are not alone in this universe! I DO the time thing. I've even spent time posrupely thinking about what time to use. AND, being the geeky kind of guy I am, I have a tendency to use values that represent computer RAM (random access memory). Such as 32, 64, 128, 256, 512, 640. I have no doubt my wife could swap stories with your wife in that regard.MUST go set my alarm for 5:12I've even got clocks in the house that are not the same time, on purpose. How quirky is that? I'd probably change the time on my phone if the Sprint network didn't countermand my actions.I also love prime numbers and multiples of prime numbers.And I had to jump in because you mentioned one of my favorite authors Dean Koontz.Heather love the idea of climbing a tree when things get tough. Nice image.blessings,david
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