cerevisiae	pombe	E. coli	human	function
Rad51, Dmc1(meiotic)	rhp51	RecA	Rad51, Rad51-B,C,D, XRCC-2,3 Dmc1(meiotic)	strand invasion, (h)lethal
Rad52	rad22A, rad22B(meiotic) rti1(similar)		rad52	strand annealing, assist rad51, very subtle human function
Rad54	rhp54		rad54-A,B/ATR-X/HX2	chromatin remodeling
Rdh54/tid1	rdh54		rad54-B	second rad54 homolog
Rad55	rhp55		xrcc2-3?	assist rad51
Rad57	rhp57		xrcc2-3?	assist rad51
			XRCC1	nick repair (with pol β and DNA ligase III)
Rad55/57?	rhp55/57?		XRCC2	part of Rad51-B,C,D,X2 complex
Rad55/57?	rhp55/57?		XRCC3	part of Rad51-C,X3 complex. resolve Holliday junctions?
Rad50	rad50		rad50	trim DSB ends. rad50/mre11/xrs2 (MRX) complex
Mre11	rad32		mre11	trim DSB ends. rad50/mre11/xrs2 (MRX) complex
Xrs2	nbs1		nbs1	trim DSB ends. rad50/mre11/xrs2 (MRX) complex
Sae2	Ctp1		CtIP (Ctp1)	nuclease to allow initial DSB 5' resection (with MRX complex)
Dna2			Dna2	main nuclease to allow DSB 5' resection
exoI			exoI	alternative / contributory nuclease to allow DSB 5' resection
srs2			rtel1	remove rad51 from ssDNA
yku70/hdf1			Ku70/XRCC6	endjoining, heterdimer with Ku80
yku80/hdf2			Ku80/XRCC5	endjoining, heterodimer with Ku70
not found			DNA-PKcs/XRCC7	DNA-dependent kinase, partners with Ku70/80 heterdimer
lif1			XRCC4	heterodimer with lig4
dnl4			lig4	ligase, heterodimer with xrcc4
			XRCC9/Fanc-G	Fanconi anemia complementation group G
			XRCC11/BRCA2/Fanc-D1	hereditary breast cancer, Fanconi anemia
	rad9		rad9	rad9/hus1/rad1 hetertrimer, repair polymerase sliding clamp loader (RFC equivalent)?
	rad1		rad1	part of "911" complex with rad9 and hus1
	hus1		hus1	part of "911" complex with rad9 and rad1, hydroxyurea sensitive
			XPA	NER; xeroderma pigmentosum
rad25/ssl2			XPB/ERCC3	NER; xeroderma pigmentosum, cockayne's, tricothiodystrophy
rad4			XPC	global genome NER (only); xeroderma pigmentosum
rad23			HR23A / HR23B	XPC cofactors
			cen2	XPC cofactor
	rad3		XPD/ERCC2	NER, G2 checkpoint; xeroderma pigmentosum, cockayne's, tricothiodystrophy
			XPE	NER; xeroderma pigmentosum
rad1	rad16/swi9		XPF/ERCC4	heterodimer with (sc)rad10, cut off 3' ended ss flaps; xeroderma pigmentosum
rad10	swi10		ERCC1	heterodimer with (sc)rad1, 5' (wrt damage) NER flap endonuclase
rad27/fen1	rad2/fen1	N-term of DNA polI (polN)	XPG/ERCC5	NER; cut 5' ended ss flaps
rad2			XPG	NER, early-onset cockayne's (transcription coupled repair)
			CSA/ERCC8	transcription coupled repair (Cockayne's)
rad26			CSB/ERCC6	cockayne's syndrome (transcription coupled repair)
	rad13			NER
	rad15			NER
	rad17			G2 checkpoint
ddc2?	rad26			G2 checkpoint
msh2		mutS	msh2	msh2/3 or msh2/6 heterdimer, mismatch repair of bases, loops
msh3		mutS	msh3	msh2/3 heterdimer, mismatch repair of loops
msh6/gtbp		mutS	msh6	msh2/6 heterodimer, mismatch repair of bases
mlh1		mutL	mlh1	mlh1/(h)pms2 heterodimer, mismatch repair
pms1		mutL	pms2	mlh1/(h)pms2 heterodimer, mismatch repair
pms2		mutL	pms1
sgs1				helicase to allow DSB 5' resection
sgs1	rqh1	recQ	recql1	assists BLM? no disease known
sgs1	rqh1	recQ	WRN/recql2	Werner syndrome
sgs1	rqh1	recQ	BLM/recql3	Bloom syndrome
sgs1	rqh1	recQ	RTS/recql4	Rothmund-Thompson syndrome
sgs1	rqh1	recQ	recql5	assists BLM? no disease known
yen1			GEN1	Holliday junction resolution
mec1	rad3		ATR	replication fork failure checkpoint, (h)lethal
tel1			ATM	DSB checkpoint, ataxia-telangiectasia
rad53			chk2	checkpoint signal transducer
		uvrA, uvrB		holliday junction branch migration
		uvrC		holliday junction resolvase
		rusA		holliday junction resolvase
mus81	mus81		mus81	similar to Rad1/10 but more active on branches than flaps
mms4	eme1		hMMS4	accessory to mus81, branch nickase
spo11	rec12		spo11	generate meiotic double-strand breaks for synapsis/recombination
rfa1	rad11			largest subunit of the heterotrimeric eukaryotic single-stranded binding protein RPA
Rev3			DNA pol ζ	Pol Zeta, catalytic subunit, translesion polymerase
Rev7			DNA pol ζ	Pol Zeta, accessory component, translesion polymerase
Rad30			DNA pol η	Pol Eta, translesion polymerase, deficient in XP-V, one of the DNA polymerases to extend HR D-loops