cerevisiae
| pombe
| E. coli
| human
| function |
Rad51, Dmc1(meiotic)
| rhp51
| RecA
| Rad51, Rad51-B,C,D, XRCC-2,3 Dmc1(meiotic)
| strand invasion, (h)lethal |
Rad52
| rad22A, rad22B(meiotic) rti1(similar)
|
| rad52
| strand annealing, assist rad51, very subtle human function |
Rad54
| rhp54
|
| rad54-A,B/ATR-X/HX2
| chromatin remodeling |
Rdh54/tid1
| rdh54
|
| rad54-B
| second rad54 homolog |
Rad55
| rhp55
|
| xrcc2-3?
| assist rad51 |
Rad57
| rhp57
|
| xrcc2-3?
| assist rad51 |
|
|
| XRCC1
| nick repair (with pol β and DNA ligase III) |
Rad55/57?
| rhp55/57?
|
| XRCC2
| part of Rad51-B,C,D,X2 complex |
Rad55/57?
| rhp55/57?
|
| XRCC3
| part of Rad51-C,X3 complex. resolve Holliday junctions? |
Rad50
| rad50
|
| rad50
| trim DSB ends. rad50/mre11/xrs2 (MRX) complex |
Mre11
| rad32
|
| mre11
| trim DSB ends. rad50/mre11/xrs2 (MRX) complex |
Xrs2
| nbs1
|
| nbs1
| trim DSB ends. rad50/mre11/xrs2 (MRX) complex |
Sae2
| Ctp1
|
| CtIP (Ctp1)
| nuclease to allow initial DSB 5' resection (with MRX complex) |
Dna2
|
|
| Dna2
| main nuclease to allow DSB 5' resection |
exoI
|
|
| exoI
| alternative / contributory nuclease to allow DSB 5' resection |
srs2
|
|
| rtel1
| remove rad51 from ssDNA |
yku70/hdf1
|
|
| Ku70/XRCC6
| endjoining, heterdimer with Ku80 |
yku80/hdf2
|
|
| Ku80/XRCC5
| endjoining, heterodimer with Ku70 |
not found
|
|
| DNA-PKcs/XRCC7
| DNA-dependent kinase, partners with Ku70/80 heterdimer |
lif1
|
|
| XRCC4
| heterodimer with lig4 |
dnl4
|
|
| lig4
| ligase, heterodimer with xrcc4 |
|
|
| XRCC9/Fanc-G
| Fanconi anemia complementation group G |
|
|
| XRCC11/BRCA2/Fanc-D1
| hereditary breast cancer, Fanconi anemia |
| rad9
|
| rad9
| rad9/hus1/rad1 hetertrimer, repair polymerase sliding clamp loader (RFC equivalent)? |
| rad1
|
| rad1
| part of "911" complex with rad9 and hus1 |
| hus1
|
| hus1
| part of "911" complex with rad9 and rad1, hydroxyurea sensitive |
|
|
| XPA
| NER; xeroderma pigmentosum |
rad25/ssl2
|
|
| XPB/ERCC3
| NER; xeroderma pigmentosum, cockayne's, tricothiodystrophy |
rad4
|
|
| XPC
| global genome NER (only); xeroderma pigmentosum |
rad23
|
|
| HR23A / HR23B
| XPC cofactors |
|
|
| cen2
| XPC cofactor |
|
| rad3
|
| XPD/ERCC2
| NER, G2 checkpoint; xeroderma pigmentosum, cockayne's, tricothiodystrophy |
|
|
| XPE
| NER; xeroderma pigmentosum |
rad1
| rad16/swi9
|
| XPF/ERCC4
| heterodimer with (sc)rad10, cut off 3' ended ss flaps; xeroderma pigmentosum |
rad10
| swi10
|
| ERCC1
| heterodimer with (sc)rad1, 5' (wrt damage) NER flap endonuclase |
rad27/fen1
| rad2/fen1
| N-term of DNA polI (polN)
| XPG/ERCC5
| NER; cut 5' ended ss flaps |
rad2
|
|
| XPG
| NER, early-onset cockayne's (transcription coupled repair) |
|
|
| CSA/ERCC8
| transcription coupled repair (Cockayne's) |
rad26
|
|
| CSB/ERCC6
| cockayne's syndrome (transcription coupled repair) |
|
| rad13
|
|
| NER |
|
| rad15
|
|
| NER |
|
| rad17
|
|
| G2 checkpoint |
ddc2?
| rad26
|
|
| G2 checkpoint |
msh2
|
| mutS
| msh2
| msh2/3 or msh2/6 heterdimer, mismatch repair of bases, loops |
msh3
|
| mutS
| msh3
| msh2/3 heterdimer, mismatch repair of loops |
msh6/gtbp
|
| mutS
| msh6
| msh2/6 heterodimer, mismatch repair of bases |
mlh1
|
| mutL
| mlh1
| mlh1/(h)pms2 heterodimer, mismatch repair |
pms1
|
| mutL
| pms2
| mlh1/(h)pms2 heterodimer, mismatch repair |
pms2
|
| mutL
| pms1
| |
sgs1
|
|
|
| helicase to allow DSB 5' resection |
sgs1
| rqh1
| recQ
| recql1
| assists BLM? no disease known |
sgs1
| rqh1
| recQ
| WRN/recql2
| Werner syndrome |
sgs1
| rqh1
| recQ
| BLM/recql3
| Bloom syndrome |
sgs1
| rqh1
| recQ
| RTS/recql4
| Rothmund-Thompson syndrome |
sgs1
| rqh1
| recQ
| recql5
| assists BLM? no disease known |
yen1
|
|
| GEN1
| Holliday junction resolution |
mec1
| rad3
|
| ATR
| replication fork failure checkpoint, (h)lethal |
tel1
|
|
| ATM
| DSB checkpoint, ataxia-telangiectasia |
rad53
|
|
| chk2
| checkpoint signal transducer |
|
|
| uvrA, uvrB
|
| holliday junction branch migration |
|
|
| uvrC
|
| holliday junction resolvase |
|
|
| rusA
|
| holliday junction resolvase |
mus81
| mus81
|
| mus81
| similar to Rad1/10 but more active on branches than flaps |
mms4
| eme1
|
| hMMS4
| accessory to mus81, branch nickase |
spo11
| rec12
|
| spo11
| generate meiotic double-strand breaks for synapsis/recombination |
rfa1
| rad11
|
|
| largest subunit of the heterotrimeric eukaryotic single-stranded binding protein RPA |
Rev3
|
|
| DNA pol ζ
| Pol Zeta, catalytic subunit, translesion polymerase |
Rev7
|
|
| DNA pol ζ
| Pol Zeta, accessory component, translesion polymerase |
Rad30
|
|
| DNA pol η
| Pol Eta, translesion polymerase, deficient in XP-V, one of the DNA polymerases to extend HR D-loops |